Jack Testosterone
Replacement Program:

Jack Health Weight Loss Program:

Your Injectable TRT Prescription

Your Injectable TRT Prescription

Welcome to the program! 👋🏻

Welcome to the program! 👋🏻

We’re glad you’re here.

We want to thank you for choosing Jack Health. This webpage overviews the most important information about your Natesto® prescription:

We’re glad you’re here.

We want to thank you for choosing Jack Health. This webpage overviews the most important information about your Natesto® prescription:

Product Information

Product Information

Here’s a quick breakdown of your new prescription:

What is TRT?

Testosterone is a hormone found in the body that helps promote male characteristics and maintain normal development.

Testosterone Replacement Therapy (TRT) is a medical treatment for low testosterone.

Approximately 25% of men aged 40-62 years experience low testosterone.

Testosterone comes in several forms, including oral capsules, topical patch and cream, and injection. They all work to increase levels of testosterone in your body.

Testosterone levels in a normal range positively affect your vitality, libido and energy levels.

How do I know if I have low T?

Common symptoms of low testosterone include decreased libido, fatigue, erectile dysfunction and mood changes. However, you must also complete bloodwork to determine if your testosterone levels are also low, and that there is not another primary cause for these symptoms.

What causes low T?

There can be several other medical conditions that can decrease your testosterone or are associated with low testosterone such as obesity, sleep apnea, type 2 diabetes, metabolic syndrome, osteoporosis, HIV/AIDs and some medications. Improving testosterone levels can help improve body composition in these conditions, notably, metabolic syndrome and obesity with a combination of dietary changes and exercise.

How to Use & Keep Using

How to Use & Keep Using

Here’s how to use the medication

Priming:

Prime the nasal spray before first use. Turn the spray upside down and press down on the pump 10 times. If any drug comes out during priming, wash down the sink with warm water. Wipe the tip with a clean, dry, tissue. Note: You only have to do this once for each dispenser.

Giving your Dose:

Blow your nose before use, and remove the cap from the dispenser.

Place your index finger on the pump in front of a mirror, and insert the spray into the nose, slowly advancing the tip of the dispenser upwards until your finger reaches the base of the nose. Tilt the spray so that the opening touches the outer wall of your nose. This ensures that the gel gets applied to the nasal wall.

Completely depress the pump 1 time in the nostril, and remove the spray, while wiping the tip along the inside of the outer wall of your nostril to fully transfer the gel.

Repeat the above steps in your other nostril.

Use a clean, dry tissue to wipe the tip of the spray, and replace the cap.

Try not to blow your nose, sniff or insert anything into your nostril for 1 hour after administering your Natesto®.

Depending on your prescription you may be asked to spray twice a day or three times a day in each nostril. Be sure to read your prescription label carefully.

Each dispenser of Natesto will last you 15 days (if you take the medication twice daily) or 10 days (if you take the medication three times daily).

Tips & Precautions

Tips & Precautions

Tell us if you have ever had any unusual or allergic reaction to soy or castor oil as Natesto® contains these ingredients.

If you get the drug anywhere else on your skin, other than in your nostrils, wash it off right away with soap and water.

Storage, Stability, Disposal

Storage, Stability, Disposal

Store the Natesto® at room temperature between 15° – 30°C, away from heat, moisture, and direct light. The medication expiry date is listed on each bottle and is also on the side of the box. Keep in a safe place out of reach and sight of children.

Used Natesto® bottles should be discarded in household trash in a manner that prevents accidental exposure by household members, especially anyone who is nursing or pregnant. Alternatively, you can return empty Natesto® bottles to your nearest pharmacy for disposal.

Side Effects

Side Effects

Common side effects:

  • Acne

  • Headache

  • Skin irritation, redness or rash at the application site

  • Abnormal lab test results (hematocrit, hemoglobin, PSA)

  • Urinary symptoms

  • Change in mood

  • Loss of hair and baldness (alopecia)

  • High blood pressure

  • Weight gain

  • Low sperm count (Oligospermia)

Uncommon side effects:

  • Testis disorders

  • Enlarged prostate (benign prostatic hyperplasia)

  • Depression

  • Prolonged or painful erection

  • Sleep disturbances caused by breathing problems (sleep apnea)

  • Aggression or aggressive behaviour

  • Breast enlargement and breast pain (Gynecomastia)

  • Increased or irregular heart rate

  • Blood clot in the lungs or the legs

Contraindications, warnings and drug interactions

Contraindications, warnings and drug interactions

Testosterone replacement therapy (TRT) is not suitable for everyone. There are some medical conditions and situations where TRT should be avoided or used with caution.

Contraindications:

  • Prostate cancer or breast cancer: If you have a history of prostate cancer or breast cancer, TRT is not recommended as it can promote growth of these types of cancer cells.

  • Pregnancy and breastfeeding: TRT is contraindicated in people who are pregnant or breastfeeding as it can cause harm to the fetus or infant.

Warnings:

  • Liver or kidney disease, heart disease, high cholesterol or blood pressure, and diabetes: If you have any of these conditions, it is important to talk to your doctor before starting TRT as it can worsen these conditions.

  • Sleep apnea: TRT can worsen sleep apnea, which is a condition where breathing is interrupted during sleep. If you have sleep apnea, it is important to discuss the risks and benefits of TRT with your doctor before starting treatment.

Drug Interactions:

  • Certain medications can interact with TRT and increase the risk of side effects. It is important to inform your doctor of all medications, including over-the-counter and herbal supplements, that you are taking before starting TRT.

If you have any concerns about whether TRT is right for you, don’t hesitate to use the medical chat and discuss the potential benefits and risks of treatment.

Pharmacy FAQs

Pharmacy FAQs

How do I get my prescription?

Once your prescription is ready you can either pick it up at our on site location (2620 Bristol Circle, Oakville, Unit 400) or have your medication delivered monthly to your home for free. We ship across Canada to all regions except for: New Brunswick, Northwest Territories, Prince Edward Island, Nunavut, and Yukon. Once your order has been processed, you’ll be provided with a tracking number and can expect your delivery within 3-5 days. You will need to sign for your package, or pick it up with valid ID from Canada Post.

How do I get a refill?

You will be auto-refilled every 1-3 months as long as you remain on the program and keep up with your bloodwork.

How do we connect if there’s any problems?

If you have questions about your prescription or dosage, you can contact our pharmacists at pharmacy@jackhealth.caYou can also contact our Virtual Care Coordinator, Bianca Wallace, at bianca.jessica@jackhealth.ca For other medical questions, like side effects, log into your account and head to the Medical Chat tab.

How does follow up work?

During month 1-3:

  • We start regular check-ins and content to track and support your progress

  • You will receive several emails from us about how to build healthy habits – written by our medical team

  • You will chat with our medical team every 3 months to check your symptoms, and review your bloodwork

  • We encourage you to book time with our Wellness team (Registered Dietitians, Registered Kinesiologists, and mental wellness experts)

Every 3 months thereafter:

  • Every three months you’ll get new bloodwork done so we can review and make sure you’re progressing well with no issues

  • A nurse practitioner follow up with you via the Medical Chat every 3-5 months

General FAQs

General FAQs

Can I drink alcohol while on this medication?

In general, drinking alcohol excessively can have short and long term effects to hormone balance, including testosterone – the primary male sex hormone. Alcohol can disrupt testosterone productions by interfering with the glands that secrete testosterone. Heavy drinkers (i.e. more than 15 drinks/week) tend to have lower testosterone levels than those who consume a moderate amount of alcohol.

Thus, in general, it is recommended to minimize the consumption of alcohol while on testosterone replacement therapy – in order to increase the efficacy of therapy.

What if I get sick with a flu or flu like symptoms while on treatment?

While rare, it’s possible to experience flu like symptoms while on testosterone replacement therapy. These side effects should be temporary and manageable with rest, adequate fluid intake and over the counter medications like Advil and Tylenol for pain management. Please reach out to our team if you are having prolonged flu like side effects or severe issues while on treatment.

Can I switch medications if it doesn’t work?

There are different formulations of testosterone available as replacement therapy, including patches, injections, gels and capsules. However, all have a side effect profile that may be unfavourable for patients. As well, these products may be back ordered or discontinued by the manufacturer.

In terms of knowing whether or not therapy is working for you, effects on sexual interest appear after 3 weeks and plateauing at 6 weeks, with no further increments expected beyond. Changes in erections/ejaculations may require up to 6 months. Effects on quality of life manifest within 3–4 weeks, but maximum benefits take longer. Please keep these timelines in mind while on therapy and give it time to work! If you have concerns, please use the medical chat to discuss them with our health care providers.

Contact Us

Contact Us

For general questions, you can reach us at: hello@jack.health or by chatting with us on our website.If you have questions about your prescription or dosage, you can contact our pharmacists at pharmacy@jackhealth.ca or by phone at 905-291-7970.

For other medical questions, like side effects, log into your account and head to the Medical Chat tab.

Extra Reading

Extra Reading

If you’d like to read the full product instruction booklet from the manufacturer, click here.

If you would like to read the Patient monograph, and how to use the medication, see attached.

Join the thousands of men who are taking charge and prioritizing their health.

© 2025 Jack&Jill Health Inc.
Jack Health is not a pharmacy or a drug manufacturer.

Join the thousands of men who are taking charge and prioritizing their health.

© 2025 Jack&Jill Health Inc.
Jack Health is not a pharmacy or a drug manufacturer.

Treatments

Company

Medications

Join the thousands of men who are taking charge and prioritizing their health.

© 2025 Jack&Jill Health Inc.
Jack Health is not a pharmacy or a drug manufacturer.

Treatments

Company

Medications