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Viagra vs. Cialis vs. Levitra: Which is Better?

Written by: Jack Health Team
Reviewed by: Sarah Bento-De Sousa PharmD. RPh

Viagra, Cialis, and Levitra all stand out as the top contenders. Each of these medications has proven effective, but they differ in dosage, timing, and side effects.

Understanding these differences is crucial in choosing the most suitable medication.

What is Viagra (sildenafil)?

Viagra is a brand-name oral tablet. Viagra contains the active ingredient sildenafil.

Sildenafil (Viagra) is a phosphodiesterase-5 (PDE-5) inhibitor. PDE-5 is a protein in your body that breaks down the molecules that normally cause an erection. 

When it blocks PDE-5, sildenafil (Viagra) helps an erection occur by allowing certain muscles in the penis to relax and the penis to fill with blood.

What is Cialis (tadalafil)?

Tadalafil (Cialis) is a phosphodiesterase-5 enzyme (PDE-5) inhibitor. It works by blocking PDE-5. This is a protein in your body that breaks down the molecules that normally cause an erection. 

When it blocks PDE-5, tadalafil (Cialis) helps an erection occur by allowing certain muscles in the penis to relax and the penis to fill with blood.

What is Levitra (vardenafil)?

Vardenafil is a medication that treats erectile dysfunction. ED is the inability to achieve and sustain an erection suitable for sexual intercourse. This medication works by increasing blood flow to your penis, which helps you maintain an erection.

Viagra vs. Cialis vs. Levitra Comparison

The main difference between Viagra, Cialis, and Levitra lies in their chemical composition and the duration of their effects. These differences are crucial for patients and healthcare providers to consider when choosing the most appropriate treatment.

Active Ingredients
  • Viagra: The active ingredient is Sildenafil Citrate. 
  • Cialis: Contains Tadalafil as its active ingredient. It is known for its longer duration of action, providing an effect for up to 36 hours.
  • Levitra: Uses Vardenafil as its active component. It’s similar to sildenafil,, but it may offer slightly quicker onset of action compared to Viagra.
Uses
  • Viagra (Sildenafil): Typically takes effect within 30 minutes and lasts for about 4-5 hours. 
  • Cialis (Tadalafil): Known for its long-lasting effects, which can persist for up to 36 hours.
  • Levitra (Vardenafil): Similar to Viagra in its duration (4-5 hours) and onset (about 30 minutes), but may be slightly more selective in its pharmacological effects, which could result in fewer side effects.
Dosage for ED
 

Viagra

Cialis

Levitra

Dosage

25, 50, or 100 mg, up to once per day

5, 10, or 25 mg, up to once per day

2.5, 5, 10 or 20 mg, up to once daily

 

*Source 

  • Viagra typical dose: The typical starting dose is one 50 mg tablet. If you’re getting side effects, it can be cut down to 25 mg. If it’s not fully working, it can be increased to 100 mg.

           Interested in exploring different forms of medications that might work faster than traditional pills? Discover the               differences between another popular option and Viagra by reading our comparison of Kamagra Jelly vs Viagra,                which might offer a quicker onset of action.

  • Cialis typical dose: The typical starting dose of Cialis for occasional use is one 10 mg tablet. It can be dropped to 5 mg or increased to 20 mg depending on how you respond. The daily dose for regular use is 2.5 mg to 5 mg.
  • Levitra typical dose: The typical starting dose of vardenafil is one 10 mg tablet. It can be cut back to 5 mg or increased to a maximum of 20 mg. Vardenafil is available as a traditional pill that you swallow and a rapidly dissolving pill (which gets to work faster).
Time to Work
  • Viagra: It can start to take effect in as little as 30 minutes. But usually you’ll have to wait 45 to 60 minutes before it reaches maximum effect. Then it keeps working for up to 8 hours.
  • Cialis: It can start working in as quickly as 30 minutes, but you may have to wait up to 2 hours for it to reach the point when it’s most effective. The effects of Cialis last for up to 36 hours, helping you with erections at any point in that time period.
  • Levitra: It can start working in as quickly as 15 minutes, but peak effects can take up to 1 hour. Then, it will keep working for 4 to 5 hours.


As you consider pharmaceutical options like Viagra,, you might also be curious about natural alternatives. Learn more about how herbal supplements compare by checking out our detailed guide on Horny Goat Weed vs Viagra, which explores natural versus pharmaceutical approaches.

Tadalafil vs. Sildenafil vs. Vardenafil Effectiveness

Sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra) are considered to work equally well. There are no studies that directly compare them against each other. 

Existing studies have only looked at how well each medication compares with a placebo (a pill with no medication in it). This means no one can claim that one medication works better than the other.

Key Takeaways

  • Duration and Effectiveness: Viagra and Levitra work for 4-5 hours, while Cialis lasts up to 36 hours, offering extended flexibility.
  • Dosage Options: Viagra, Cialis, and Levitra offer varying dosages, allowing customization based on effectiveness and side effects.


While exploring individual effectiveness of Viagra and Cialis, you might wonder if it’s safe or more effective to combine the two. For detailed insights on this, read about how to safely take Viagra and Cialis together, which can help you understand the potential benefits and risks of such a combination.

Frequently Asked Questions

Does Cialis Get You Harder Than Viagra?

Cialis provides penile hardness (the ability to obtain an erection) over a longer period than Viagra because it lasts up to 18 hours, while Viagra only lasts for about 4 to 6.

Do Most Men Prefer Viagra or Cialis?

More men tend to prefer Cialis because it lasts longer, up to 36 hours, compared to Viagra’s 4-6 hours. This extended duration allows for more spontaneity, which many find appealing. 

Which ED medication has the fewest side effects?

All three medications, Viagra, Cialis, and Levitra, can cause similar side effects such as headache, flushing, or indigestion. However, the choice of medication often depends on individual reactions and health conditions.

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